The U.S. Environmental Protection Agency (EPA) announced on August 13, 2025, that it has released a proposed registration decision for a new active ingredient, fluoxapiprolin, a broad-spectrum fungicide designed to combat a range of damaging plant diseases. The announcement opens a public comment period for the new pesticide, which the EPA has determined is safe for human health and the environment when used as directed. This decision, if finalized, would introduce a new tool for farmers to manage fungal diseases and enhance agricultural resilience.
The proposed registration covers one technical product and one end-use product containing Fluoxapiprolin. The fungicide is intended for use on a wide array of crops that are susceptible to destructive diseases, including Brassica head and stem vegetables (such as cabbage and broccoli), bulb vegetables (like onions and garlic), cucurbit vegetables (e.g., cucumbers and squash), fruiting vegetables (e.g., tomatoes and peppers), grapes, leafy vegetables, leaf petiole vegetables, and potatoes.
The introduction of fluoxapiprolin is seen as a significant addition to Integrated Pest Management (IPM) programs, which focus on a combination of common-sense practices to reduce pest damage with the least possible hazard to people and the environment. As a broad-spectrum fungicide, fluoxapiprolin is particularly effective against major diseases like downy mildew, late blight, and phytophthora blight, which can cause substantial crop losses. By providing an alternative active ingredient, this new fungicide helps farmers manage fungicide resistance, a growing challenge in modern Agriculture.
Before proposing the registration, the EPA conducted comprehensive human health and ecological risk assessments. The agency concluded that there are no "risks of concern" associated with the use of fluoxapiprolin when applied according to the label's instructions. This process involves evaluating potential risks to applicators, farmworkers, consumers, and the broader environment.
In addition to the human health and ecological risk assessments, the EPA also conducted a biological evaluation to assess potential effects on endangered and threatened species. The agency determined that the use of fluoxapiprolin would have "no effects" on listed species under the Endangered Species Act, a critical finding that streamlines the registration process.
The proposed registration decision is now available for public review and comment. The public comment period will remain open for 30 days, closing on September 12, 2025. During this time, the EPA will collect feedback from farmers, environmental groups, scientists, and the general public.
