For the Quarter Ending September 2025
North America
• In the United States, the Doxepin Hydrochloride Price Index rose quarter-over-quarter in Q3 2025, driven by escalating production costs.
• Production costs increased due to a 2.6% PPI rise in August 2025 and higher Q3 2025 energy prices.
• Demand for Doxepin Hydrochloride was supported by strengthened US pharmaceutical market sentiment in Q3 2025.
• A 4.3% unemployment rate and 5.42% retail sales growth in September 2025 bolstered Doxepin Hydrochloride demand.
• Overall chemical demand weakened in Q3 2025, with new chemical orders declining, impacting broader supply.
• US tariffs on pharmaceutical imports and APIs contributed to inflationary effects on drug production costs in 2025.
• Chemical industry inventories shrank in Q3 2025 due to accelerating destocking, tightening supply.
• The Doxepin Hydrochloride price forecast indicates continued upward pressure from sustained input cost increases.
Why did the price of Doxepin Hydrochloride change in September 2025 in North America?
• Production costs rose from a 3.0% CPI increase in September 2025 and higher U.S. natural gas prices.
• Demand was supported by a low 4.3% unemployment rate in September 2025, increasing healthcare access.
• US tariffs on pharmaceutical imports in 2025 created inflationary effects on drug production expenses.
APAC
• In China, the Doxepin Hydrochloride Price Index fell quarter-over-quarter in Q3 2025, influenced by declining production costs and overcapacity.
• Doxepin Hydrochloride production costs decreased in Q3 2025, driven by a 2.3% year-on-year fall in PPI and lower feedstock costs.
• Doxepin Hydrochloride demand outlook remains stable, supported by a 3.0% year-on-year rise in retail sales in September 2025.
• Pharmaceutical market demand strengthened in Q3 2025, driven by an aging population and chronic diseases.
• Overall chemical industry demand weakened in Q3 2025, with manufacturing activity contracting in September 2025.
• Persistent chemical industry overcapacity in China during Q3 2025 intensified market competition.
• High inventories of 1,4-Butanediol in July 2025 created downward price pressure for related chemicals.
• The Doxepin Hydrochloride Price Index forecast suggests continued pressure due to ample supply and weak overall chemical demand.
Why did the price of Doxepin Hydrochloride change in September 2025 in APAC?
• Falling raw material costs, with PPI down 2.3% year-on-year in September 2025, reduced production expenses.
• Persistent chemical industry overcapacity in China during Q3 2025 intensified market competition.
• Weakening overall chemical industry demand in Q3 2025 impacted Doxepin Hydrochloride pricing.
Europe
• In Germany, the Doxepin Hydrochloride Price Index remained stable quarter-over-quarter in Q3 2025, influenced by softening producer prices.
• Doxepin Hydrochloride production costs saw mixed trends in Q3 2025, with producer prices declining 1.7% year-over-year in September 2025.
• Raw material costs for the German chemical industry remained elevated during Q3 2025, with CPI at 2.4% year-over-year in September 2025.
• Demand for Doxepin Hydrochloride was supported by an expanding pharmaceutical market and low 3.9% unemployment in September 2025.
• Low consumer confidence, at -23.6 index in September 2025, presented a bearish outlook for Doxepin Hydrochloride demand.
• Germany's Manufacturing Index contracted in September 2025, indicating a slowdown in overall industrial activity.
• Industrial production in Germany declined by 1.0% year-over-year in September 2025, affecting Doxepin Hydrochloride supply.
• Natural gas prices eased in Germany during Q3 2025, offering some relief to Doxepin Hydrochloride production costs.
Why did the price of Doxepin Hydrochloride change in September 2025 in Europe?
• Producer prices declined 1.7% year-over-year in September 2025, reducing Doxepin Hydrochloride manufacturing input costs.
• Germany's Manufacturing Index contracted in September 2025, signaling supply chain inefficiencies and higher costs.
• Low consumer confidence (-23.6 index in September 2025) tempered Doxepin Hydrochloride demand despite market expansion.
For the Quarter Ending December 2022
North America
The prices of Doxepin Hydrochloride in North America increased moderately over the first part of the fourth quarter. Consistent end-user demand from the pharmaceutical sector kept the prices of Doxepin Hydrochloride on the higher side.
Furthermore, Supply chain disruption decreased rapidly over the six months to November across multiple measures, which did not affect the market sentiments of Doxepin Hydrochloride prices as the inventories with market participants were enough to meet any immediate order.
Until November, the prices of Doxepin Hydrochloride remained on North side and were recorded at USD 168500/MT CFR Los Angeles, but then it began to collapse as December approaches owing to significant drop in its offtakes and New year holidays which results in temporary shutdown of market within the region.
APAC
In the Asia Pacific region, specifically in China, Doxepin Hydrochloride prices plummet during the fourth quarter of 2022. As per the trend, during the first half of q4, the prices inclined positively due to healthy downstream demand balanced with sufficient supplies among the market players. However, the ease in supply chain disruption and port congestion during November compared to October helped the traders and suppliers get more orders and balance the demand side. With the end of the year 2022, China's manufacturing activities began to decrease noticeably after November with a surge in COVID-19 cases. Moreover, the decrease in freight charges positively supported the price trend of Doxepin Hydrochloride. Overall, the price of Doxepin Hydrochloride noted in the mid of the fourth quarter was assembled at USD 150250 /MT FOB Shaanxi.
Europe
In the fourth quarter of 2022, the European market for Doxepin Hydrochloride followed a mixed pattern. The market trend started on a weak note up to November as the demand from the end-user sector pharmaceutical industry remained low. Following November, the prices of Doxepin Hydrochloride witnesses were assembled at USD 171190/MT CFR Hamburg in Germany. Furthermore, inquiries from the downstream sector for Doxepin Hydrochloride prices began to increase moderately in November, keeping the prices on the higher side. Towards the end of the year 2022, fresher orders declined in December due to suppliers having large stock levels due to the market's brief closure.
For The Quarter Ending September 2022
North America
The prices of Doxepin Hydrochloride experienced a sinking trend during the third quarter of 2022 in the US market. Its price commenced the month on a positive note, with healthy demand and a stable supply side of the market. Followed by the second half of Q3, the prices declined steadily owing to decreasing downstream demand and lessening inquiries from the purchasers. This resulted in the stockpiling of inventories with the market participants. Overall, within Q3 2022, the prices witnessed record sloping tendency due to varying demand dynamics, suspended shipments, and rising inflation, with values demonstrated at USD 166400 /MT CFR Los Angeles.
APAC
The Doxepin Hydrochloride API market witnessed a descending pricing trend during the third quarter of 2022 in the Asia Pacific region, backed by the pandemic conditions and worsened climatic conditions, which affected the production units and trading activities. Strict covid-policies and lockdown imposition in some of the exporting countries' major ports significantly affected the Doxepin Hydrochloride market sentiments. The prices increased due to increased demand from the downstream pharmaceutical industry in regional and overseas markets during the first half of the third quarter. Furthermore, the prices went down towards the end of q3, keeping the inventories on the higher side. At the termination of Q3 2022, the value accessed at USD 147500 /MT FOB Shaanxi in the Chinese market.
Europe
The market of Doxepin Hydrochloride mimics similar pricing sentiments in the European region during the third quarter of 2022. At the start of Q3, the prices of Doxepin Hydrochloride depreciated in the European region, with dulled demand from the consumer end. Furthermore, lessening customer inquiries resulted in the piled-up of stocks with the market participants, which negatively impacted the market sentiments of Doxepin Hydrochloride in Germany. Also, stockpiling amongst the domestic merchant propelled them to lower the Doxepin quotation for the consumers and focus on the destocking processes. With the ending of q3, the prices of Doxepin Hydrochloride got settled at USD 171310 /MT CFR Hamburg in Germany.
For Quarter Ending June 2022
North America
Doxepin HCL prices witnessed a descending trend throughout the second quarter because of fluctuating downstream demand from the end-user sector. Additionally, the weaker demand kept the inventories on the higher side, with the market participants propelling them to reduce their prices and focus on the destocking processes. Furthermore, in the third quarter's first half, the prices demonstrated were on the higher side owing to higher requirements and less supply within the domestic market. With the start of August, the prices went down stably, keeping the inventories on the upper side. Moreover, towards the end of the third quarter, the prices recorded for Doxepin Hydrochloride were settled at USD 164000/MT CFR Los Angeles.
APAC
In APAC, the price for Doxepin HCL was in ascending order throughout the second quarter of 2022, owing to the varying downstream demand from the pharma sector in the first half of Q2. However, demand picked up in the second half after the market sentiments improved in China. Doxepin HCL is mainly utilized in the treatment of depression and anxiety. Manufacturers had sufficient inventories to support the end-user requirement in the first half of the third quarter, which resulted in the stable price trend of Doxepin Hydrochloride. At the same time, port congestion and soaring freight charges led to the supply disruption alongside mild demand fundamentals, ultimately leading to the see-sawing price trend of Doxepin HCL in the Indian market. Towards the termination of q2 the prices went high and were settled at USD 147000 /MT FOB Shaanxi.
Europe
During Q2 2022, the prices of Doxepin HCL in Europe followed the Asian price trend. Sufficient availability amid consistent offtakes in the end-user industries impacted the pricing as demand from end-use applications like antidepressants remained constant throughout the considered period. Furthermore, raw material thionyl chloride and dimethyl methylamine costs had progressively fluctuated for some time as availability in the nation have been temporarily unstable, affecting total product availability. Meanwhile, the Russia-Ukraine war also led to a slowdown in economic productivity, which has created volatility in its market prices. Consequently, the suppliers had sufficient inventories to support consumers' demand, leading to the ambiguous market for Doxepin HCL.Towards the termination of q2 the prices went high and were settled at USD 180890 /MT CFR Hamburg.
